Hemodynamic response function (HRF) variability confounds resting-state fMRI functional connectivity

Brain Connections – Resting State fMRI Functional Connectivity

With the introduction of electroencephalography (EEG) in 1930, researchers began to explore spontaneous activity in the brain by recording the individual, independently of any task. Subsequently, evoked potential studies, where electrical potentials were recorded at the onset of a stimulus, marked a milestone in brain research. Utilizing such methods coupled with experimental psychology, resear...

Resting state functional connectivity predicts neurofeedback response

Tailoring treatments to the specific needs and biology of individual patients-personalized medicine-requires delineation of reliable predictors of response. Unfortunately, these have been slow to emerge, especially in neuropsychiatric disorders. We have recently described a real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback protocol that can reduce contamination-related anx...

Support vector classification analysis of resting state functional connectivity fMRI

A Longitudinal Model for Functional Connectivity Using Resting-State fMRI

Many neuroimaging studies collect functional magnetic resonance imaging (fMRI) data in a longitudinal manner. The current fMRI modeling literature lacks a generally applicable model appropriate for longitudinal designs. In this work, we build a novel longitudinal functional connectivity (FC) model using a variance components approach. First, for all subjects’ visits, we account for the autocorr...

Vascular Modulation of Resting-State fMRI Functional Connectivity

Widely used in resting-state fMRI functional connectivity measurement (fcMRI), the BOLD signal is an indirect measure of neuronal activity, inherently modulated by vascular physiology. Notably, cerebrovascular reactivity (CVR) varies across individuals irrespective of neuronal changes, with unknown implications, compromising fcMRI interpretation. This work quantifies the relationship between CV...